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Availability of folate bound to folate-binding protein: environmental effects

Authors: M.L. Hutchinson-Jones, T. Treloar and P.F. Nixon


Milk contains folate-binding protein (FBP), which can be purified from whey protein concentrate (WPC). FBP binds folate vitamins with high affinity and has been shown to greatly stabilise otherwise very labile folates (Hutchinson et al. 2000). Binding of FBP to folate is affected by the physical state of the FBP (Jones et al. 2000). The effect of FBP on the bioavailability of folate is under investigation. This paper shows that this function is dependent on the environment of the FBP.

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