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Weight loss using meal replacements high in glycomacropeptide-enriched whey powder

Authors: J.B. Keogh and P.M. Clifton


Cholecystokinin (CC K) is a peptide hormone that causes gallbladder contraction and pancreatic enzyme secretion for the digestion of protein and fat. It is also thought to have a role in satiety. It has been reported that glycomacropeptide (GMP) stimulates the release of CC K and may contribute to increased satiety and reduced energy intake. The aim of this study was to examine after six months whether greater weight loss could be achieved with a GMPenriched whey powder meal replacement compared to a skim milk protein powder meal replacement. In a randomised, double blind, parallel design, body composition measured by dual-energy X-ray absiorptiometry (DEXA) and cardiovascular disease (CVD) risk factors were measured at baseline and 6 months. The weight loss strategy used meal replacements (MR) containing 33 g protein from GMPenriched- whey-protein-isolate, or skim-milk-protein-powder (SMPP) and 954kJ kJ/sachet. Volunteers were asked to consume 2 MR/day instead of 2 meals for 6 months. One hundred and twenty seven participants (34 men, 99 women, 95.5±15.4 kg, BMI 33.4±3.4 kg/m2, 50.0±12.4 yr) commenced and 82 completed the 6 month study. After 6 months weight loss was 9.5±5.8 vs 11.0±6.0 kg, GMP and SMPP respectively (p<0.001 compared with baseline) with no differences between treatments. Total and LDL-cholesterol, triglycerides, glucose, insulin, systolic and diastolic blood pressure decreased at 6 months (All p<0.01 compared with baseline with no difference between treatments). We conclude that weight loss using dairy protein-based meal replacements achieved a clinically meaningful weight loss with benefics on markers of CVD risk but GMP had no additional effect using this study design.

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